Fluorescence In Situ Hybridization (FISH)

Fluorescence in situ hybridization uses fluorescently labeled DNA probes that bind to complementary target sequences on chromosomes or within nuclei. The resulting signals allow researchers to investigate specific genomic regions.

FISH is useful for detecting selected chromosomal rearrangements, gene amplifications, deletions, and chromosome copy-number changes. Unlike conventional karyotyping, it can target particular sequences with greater specificity, but its findings depend on the probes selected.